Thermogenesis at the cellular level requires the function of uncoupling proteins, which are capable of dissipating the proton gradient across the mitochondrial inner membrane while uncoupling it from the process of ATP production, but instead, for heat generation. In mammals, two types of fat cells are involved in the process of non-shivering thermogenesis: (1) classic brown adipocytes, which are derived from a myf-5 positive muscle-like cellular lineage, are the main components of brown fat and the major players in heat generation; (2) "brown-like" adipocytes residing within white adipose depots that are also referred to as "beige" or "brite" adipocytes. A common feature of both types of thermogenic fat cells is that they contain high density of mitochondria and selectively express high levels of the thermogenic marker gene uncoupling protein 1 (UCP1).

Animal studies have clearly shown that the thermogenic activity of brown fat has a positive effect on maintaining whole body metabolic homeostasis. The ablation of brown fat or UCP1 knock-out leads to reduced energy expenditure and the onset of obese phenotype. The molecular aspects controlling/affecting thermogenic adipocyte development and function have been studied extensively, and among them, the epigenetic mechanisms were found to have significant effects. Epigenetic mechanisms include post-translational modifications (PTMs) on histones, DNA methylation, non-coding RNAs (miRNAs and long non-coding RNAs) and, more broadly, PTMs on non-histone regulators. In the last decade, numerous lines of evidence have emerged supporting the fundamental involvement of epigenetic modifications during adaptive thermogenesis.

IPGGS (Journal of Genomics and Gene Study) Research Topics solicit new submissions which insights into the epigenetic regulation of adaptive thermogenesis, in-depth analysis and discussion of the current available experimental results in this field, or the outlook for future directions.

It gives us great pleasure to announce the call for paper on the occasion of 08^th Anniversary of the Journal at special and hefty discount of up to 50 percent on one-time article processing charge. Prospective academicians, immunologists and scientists are encouraged to utilize this opportunity to get their articles reviewed, processed and published at relatively faster pace and at lower charges. In addition to this the authors who publish with us during the year-long celebrations will also be eligible for academic awards recommended by the Editorial panel.

The journal invites different types of articles including original research article, review articles, short note communications, case reports, Editorials, letters to the Editors and expert opinions & commentaries from different regions for publication.

A standard EDITORIAL TRACKING SYSTEM is utilized for manuscript submission, review, editorial processing and tracking which can be securely accessed by the authors, reviewers and editors for monitoring and tracking the article processing. Manuscripts can be uploaded online at Editorial Tracking System or forwarded to the Editorial Office at genomics@geneticjournals.com. 

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Journal of Genomics & Gene Study
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