The most inspiring article in the Journal of Nephrology and Urology


The most inspiring article in the Journal of Nephrology and Urology

Journal of Nephrology and Urology published many of inspiring articles. Here we are explain a short note on article entitled “Prognostic Factors of Renal Impairment in Multiple Myeloma in Senegal”

Journal of Nephrology and Urology is an Open Access peer-reviewed publication that discusses current research and advancements in diagnosis and management of kidney disorders as well as related epidemiology, pathophysiology and molecular genetics.

The occurrence of renal impairment in multiple myeloma is a major turning point in the evolution of this incurable malignant hemopathy. This is the main prognostic factor and more and more authors report its major impact on the long-term overall survival of these patients. The aim of this study was to describe the prognosis and to determine the prognostic factors of renal involvement in multiple myeloma

Multiple myeloma is the most common dysglobulinemia. It is defined by a plasmocytosis >10% with or without CRAB criteria such as anemia, hypercalcemia, renal failure, and the presence of bone lesions. It is an incurable hematological malignancy and its gravity is due to its many complications, infectious, neoplastic, hematological (AL amyloidosis), renal and bone often disabling. The kidney is the major target of multiple myeloma, nearly 40% of myeloma patients will develop kidney disease and among them 10 to 15% will need dialysis. The high incidence of advanced renal impairment at the time of diagnosis has a significant impact on the overall survival of these patients.

Anatomo-clinical forms of renal damage observed in our patients were of good prognosis. But their management was late because of the often lengthy delay between the clinicalbiological and histological diagnosis as well as the effective start of the treatment which sometimes required a specific treatment that did not exist in Senegal. 

Prognosis of renal impairment in multiple myeloma in Senegal remains poor because of the delay in management between the diagnosis of myeloma and the actual start of treatment. Predictors of kidney disease are dominated by age, gender, high blood pressure, diabetes, NSAIDs, exposure to toxic products, and herbal intake; the prognostic factors are the same reported in the current literature. In our work, renal impairment is related to the male genus, proteinuria and hyperprotidemia.

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